Research & Clinical Trials

Advancing Surgical Oncology

Translating research into better patient outcomes through clinical trials, collaborative studies, and evidence-based practice.

Active Research Areas

Peritoneal Surface Malignancies

  • Prognostic factors in CRS+HIPEC for colorectal peritoneal metastases
  • Novel HIPEC drug regimens and protocols
  • Quality of life outcomes after cytoreductive surgery
  • Patient selection and peritoneal cancer index optimization

Retroperitoneal Sarcoma

  • Compartmental resection outcomes
  • Neoadjuvant treatment strategies
  • Recurrence patterns and management
  • International collaborative registries
  • Lead author of the first ERAS consensus for primary retroperitoneal sarcoma surgery (Hispano-Luso consensus)

Pseudomyxoma Peritonei

  • Classification and prognosis of appendiceal pseudomyxoma
  • Long-term follow-up after complete cytoreduction
  • Role of HIPEC in low-grade and high-grade disease

Nephroprotection During HIPEC

  • Prevention of cisplatin-HIPEC associated nephrotoxicity
  • Cilastatin vs thiosulfate: comparative study
  • Renal protection biomarker monitoring

Clinical Trials

Ongoing Studies

Recruiting

Cilastatin vs Thiosulfate: Nephroprotection in CRS+HIPEC with Cisplatin

Prospective study evaluating nephroprotection with cilastatin versus sodium thiosulfate in patients undergoing CRS+HIPEC with cisplatin.

Publications

Recent Work

Consensus Guidelines on Perioperative Care in Primary Retroperitoneal Sarcoma Surgery

Annals of Surgical Oncology · 2026

DOIPubMed

ASO Author Reflections: Enhanced Recovery in Retroperitoneal Sarcoma Surgery — From Concept to Consensus

Annals of Surgical Oncology · 2026

DOI

Cuidados perioperatorios en la cirugía del sarcoma retroperitoneal primario: una encuesta hispano-lusa sobre prácticas actuales

Cirugía Española · 2026

DOI

Experience of a Referral Center with Desmoid Tumors, Part 2: A Retrospective Analysis of 109 Cases

Cancers · 2026

DOI

Desmoid Tumors — Experience from a Referral Center, Part 1: Multidisciplinary Review and Practical Recommendations

Cancers · 2025

DOI

Diagnostic Delay in Soft Tissue Sarcomas: A Review

Cancers · 2025

DOI

Ibero-American Consensus for the Management of Liver Metastases of Soft Tissue Sarcoma: Updated Review and Clinical Recommendations

Cancers · 2025

DOI

External multicentre validation of pseudomyxoma peritonei PSOGI-Ki67 classification

European Journal of Surgical Oncology · 2023

DOI

Appendiceal Mucinous Neoplasms: From Clinic to Pathology and Prognosis

Cancers · 2023

DOI

Updated Review and Clinical Recommendations for the Diagnosis and Treatment of Patients with Retroperitoneal Sarcoma by the Spanish Sarcoma Research Group (GEIS)

Cancers · 2023

DOI

Validation of a Nomogram to Predict Recurrence in Patients with Mucinous Neoplasms of the Appendix with Peritoneal Dissemination After CRS and HIPEC

Annals of Surgical Oncology · 2022

DOI

Neoadjuvant therapy impact in early pancreatic cancer: bioborderline vs. non-bioborderline

Annals of Hepato-Biliary-Pancreatic Surgery · 2022

DOI

Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy

International Journal of Molecular Sciences · 2021

DOI

Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study

The Lancet Oncology · 2021

DOI
View Full Publication List on ORCID

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